Husseini K. Manji, MD
The major focus of Dr. Manji's ongoing research is the investigation of disease- and treatment-induced changes in gene and protein expression profiles that regulate neuroplasticity and cellular resilience in mood disorders. In broad terms, his laboratories' scientific goals are to capitalize upon recent insights into our understanding of the signaling pathways mediating the effects of mood stabilizers in order to understand the pathophysiology of severe mood disorders and to develop improved therapeutics.
- Global Therapeutic Area Head, Neuroscience Research and Development, Johnson and Johnson Pharmaceutical Research and Development
- Chief, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, MD
- Visiting Professor, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY
- Director, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD
- Visiting Professor, Department of Psychiatry, Duke University, Durham, NC
- MD, 1985, University of British Columbia, Vancouver, B.C., Canada
- FRCPC, 1991, Royal College of Physicians and Surgeons of Canada, Ottawa, Ontario, Canada
- Ibrahim, L., DiazGranados, N., Franco-Chaves, J. Brutsche, N., Henter, I., Kronstein, P.,...Zarate, C. (2012). Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: Results from a 4-week, double-blind, placebo-controlled study. Neuropsychopharmacology, 37, 1526-1533.
- Koss, W. A., Einat, H., Schloesser, R. J., Manji, H. K., & Rubinow, D. R. (2012). Estrogen effects on the forced swim test differ in two outbred rat strains. Physiology & Behavior, 106(2), 81-86.
- Malkesman, O., Austin, D. R., Tragon, T., Wang, G., Rompala, G., Hamidi, A.,...Chen, G. (2012). Acute d-serine treatment produces antidepressant-like effects in rodents. The International Journal of Neuropsychopharmacology, 15(8), 1135-1148.
- Martinowich, K., Cardinale, K., Schloesser, R., Hsu, M., Greig, N., & Manji, H. K. (2012). Acetylcholinesterase inhibition ameliorates deficits in motivational drive. Behavioral and Brain Functions, 8(15), 1-14.
- Schloesser, R. J., Martinowich, K., & Manji, H. K., (2012). Mood-stabilizing drugs: Mechanisms of action. Trends in Neurosciences, 35(1), 36-46.
- Maintain the Long-Term Vision
- Questions About Comorbidity
- Stand Out From the Crowd
- The Best Place in the World to Do Research
- The Most Fascinating Medical Condition
- To Include or Not Include Comorbidities