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Husseini Manji

Husseini Manji, M.D.

The major focus of Dr. Manji's ongoing research is the investigation of disease- and treatment-induced changes in gene and protein expression profiles that regulate neuroplasticity and cellular resilience in mood disorders. In broad terms, his laboratories' scientific goals are to capitalize upon recent insights into our understanding of the signaling pathways mediating the effects of mood stabilizers in order to understand the pathophysiology of severe mood disorders and to develop improved therapeutics.

Positions

  • Chief, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, MD
  • Visiting Professor, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY
  • Director, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD
  • Visiting Professor, Department of Psychiatry, Duke University, Durham, NC

 

Education

  • M.D., 1985, University of British Columbia, Vancouver, B.C., Canada
  • F.R.C.P.C., 1991, Royal College of Physicians and Surgeons of Canada, Ottawa, Ontario, Canada

 

Relevant Publications

  • Kalivas P, Manji H. Neuroplasticity: a new window on therapeutics in neuropsychiatric disease. Neuropsychopharmacology. 2008;33(1):2.
  • Schloesser RJ, Huang J, Klein PS, Manji HK. Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology. 2008;33(1):110-133.
  • Newberg AR, Catapano LA, Zarate CA, Manji HK. Neurobiology of bipolar disorder. Expert Rev Neurother. 2008;8(1):93-110.
  • Laje G, Paddock S, Manji H, et al. Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiarty. 2007;164(10):1530-1538.
  • Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci. 2007;10(9):1089-1093.

 

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